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https://hdl.handle.net/2440/23081
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Type: | Journal article |
Title: | Using GI-specific patient outcome measures in renal transplant patients: Validation of the GSRS and GIQLI |
Author: | Kleinman, L. Kilburg, A. Machnicki, G. Faull, R. Walker, R. Prasad, R. Ambuehl, P. Bahner, U. Margolis, M. |
Citation: | Quality of Life Research, 2006; 15(7):1223-1232 |
Publisher: | Kluwer Academic Publ |
Issue Date: | 2006 |
ISSN: | 0962-9343 1573-2649 |
Abstract: | <h4>Introduction</h4>Gastrointestinal (GI) side-effects occur frequently as a result of immunosuppressant regimens used in renal transplant patients. Little effort has been made to quantify the impact of these side-effects on patients' health-related quality of life and symptom severity.<h4>Objective</h4>To assess the psychometric characteristics of two GI-specific outcome instruments (the Gastrointestinal Rating Scale (GSRS) and the Gastrointestinal Quality of Life Index (GIQLI)) for use in post-renal transplant patients.<h4>Methods</h4>Cross-sectional study conducted at 5 clinical centers in 4 countries. Patients were required to be on mycophenolate mofetil and a calcineurin inhibitor. Patients completed the GSRS, GIQLI and two generic instruments (the Psychological General Well-Being Index and the EQ-5D) at one timepoint. Reliability, construct and known groups validity were assessed.<h4>Results</h4>In general the GSRS and the GIQLI demonstrated Cronbach's alphas higher than 0.70. The GIQLI was moderately to highly correlated with the PGWB and EQ-5D. Correlations among the GSRS and generic instruments were slightly lower. The GSRS and GIQLI both distinguished between patients with and without GI complaints (all p<0.05).<h4>Conclusions</h4>The GSRS and the GIQLI are appropriate for use in a post-renal transplant population. Scores on both instruments demonstrated significant differences between renal transplant patients with GI complications and without GI complications. |
Keywords: | QUALITY-OF-LIFE MYCOPHENOLATE-MOFETIL ACUTE REJECTION GASTROINTESTINAL SYMPTOMS GASTROESOPHAGEAL-REFLUX LONG-TERM PREVENTION DISEASE IMMUNOSUPPRESSION CYCLOSPORINE |
DOI: | 10.1007/s11136-006-0053-5 |
Appears in Collections: | Aurora harvest 6 Public Health publications |
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