Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/23081
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dc.contributor.authorKleinman, L.en
dc.contributor.authorKilburg, A.en
dc.contributor.authorMachnicki, G.en
dc.contributor.authorFaull, R.en
dc.contributor.authorWalker, R.en
dc.contributor.authorPrasad, R.en
dc.contributor.authorAmbuehl, P.en
dc.contributor.authorBahner, U.en
dc.contributor.authorMargolis, M.en
dc.date.issued2006en
dc.identifier.citationQuality of Life Research, 2006; 15(7):1223-1232en
dc.identifier.issn0962-9343en
dc.identifier.issn1573-2649en
dc.identifier.urihttp://hdl.handle.net/2440/23081-
dc.description.abstract<h4>Introduction</h4>Gastrointestinal (GI) side-effects occur frequently as a result of immunosuppressant regimens used in renal transplant patients. Little effort has been made to quantify the impact of these side-effects on patients' health-related quality of life and symptom severity.<h4>Objective</h4>To assess the psychometric characteristics of two GI-specific outcome instruments (the Gastrointestinal Rating Scale (GSRS) and the Gastrointestinal Quality of Life Index (GIQLI)) for use in post-renal transplant patients.<h4>Methods</h4>Cross-sectional study conducted at 5 clinical centers in 4 countries. Patients were required to be on mycophenolate mofetil and a calcineurin inhibitor. Patients completed the GSRS, GIQLI and two generic instruments (the Psychological General Well-Being Index and the EQ-5D) at one timepoint. Reliability, construct and known groups validity were assessed.<h4>Results</h4>In general the GSRS and the GIQLI demonstrated Cronbach's alphas higher than 0.70. The GIQLI was moderately to highly correlated with the PGWB and EQ-5D. Correlations among the GSRS and generic instruments were slightly lower. The GSRS and GIQLI both distinguished between patients with and without GI complaints (all p<0.05).<h4>Conclusions</h4>The GSRS and the GIQLI are appropriate for use in a post-renal transplant population. Scores on both instruments demonstrated significant differences between renal transplant patients with GI complications and without GI complications.en
dc.language.isoenen
dc.publisherKluwer Academic Publen
dc.subjectQUALITY-OF-LIFE; MYCOPHENOLATE-MOFETIL; ACUTE REJECTION; GASTROINTESTINAL SYMPTOMS; GASTROESOPHAGEAL-REFLUX; LONG-TERM; PREVENTION; DISEASE; IMMUNOSUPPRESSION; CYCLOSPORINEen
dc.titleUsing GI-specific patient outcome measures in renal transplant patients: Validation of the GSRS and GIQLIen
dc.typeJournal articleen
dc.identifier.rmid0020061651en
dc.identifier.doi10.1007/s11136-006-0053-5en
dc.identifier.pubid52133-
pubs.library.collectionPublic Health publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Public Health publications

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