Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/23152
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The impact of nutrition of the cumulus oocyte complex and embryo on subsequent development in ruminants
Author: Thompson, J.
Citation: Journal of Reproduction and Development, 2006; 52(1):169-175
Publisher: Japanese Soc Animal Reproduction
Issue Date: 2006
ISSN: 0916-8818
1348-4400
Statement of
Responsibility: 
Jeremy G. Thompson
Abstract: Cumulus-oocyte complexes (COCs) and early embryos rely on a histotrophic nutrition source for energy production and the synthesis of macromolecules. There is accumulating evidence suggesting that the balance of supply and demand for energy and other anabolic substrates during oocyte maturation and very early stages of development programmes subsequent developmental potential, and this may include subsequent fetal growth trajectory. One example is the role of glucose (Glc) during cumulus-oocyte complex maturation. Glucose is an essential nutrient for maturation, especially its role during cumulus expansion. Our laboratory has shown that during in vitro culture, too little glucose during cumulus-oocyte complex maturation affects meiotic competence. We have focussed on glucose (Glc) metabolism through the hexosamine biosynthesis pathway (HBP) during COC maturation in vitro. The HBP in somatic cells is regarded as a "fuel-sensing" pathway and its interaction with cell signalling systems and transcriptional regulation is increasingly apparent. Up-regulation of the HBP during oocyte maturation in vitro has negative consequences for subsequent development. Another example is the role of hypoxia (low O2) during peri-compaction development. My laboratory believes that ruminant embryos during compaction, blastulation and subsequent development in the uterine cavity lack a key hypoxia responsive element. Because of this, hypoxia is important for normal development in ruminants but perturbs further development in rodents. The implication of these examples to the fundamental concept of peri-conception nutritional programming of development are discussed.
Keywords: glucose
oxygen
oocyte
embryo
development
Rights: © 2006 The Japanese Society of Animal Reproduction
DOI: 10.1262/jrd.17089
Published version: http://www.jstage.jst.go.jp/article/jrd/52/1/52_169/_article
Appears in Collections:Aurora harvest 2
Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.