Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/23359
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Type: Journal article
Title: The hypotensive response to oral fat is comparable but slower compared with carbohydrate in healthy elderly subjects
Author: Visvanathan, R.
Horowitz, M.
Chapman, I.
Citation: British Journal of Nutrition, 2006; 95(2):340-345
Publisher: C A B I Publishing
Issue Date: 2006
ISSN: 0007-1145
1475-2662
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Responsibility: 
Renuka Visvanathan, Michael Horowitz and Ian Chapman
Abstract: The objective of the present study was to determine the comparative hypotensive responses to drinks containing predominantly fat and carbohydrate (CHO) in healthy elderly subjects. Using a randomised, cross-over study, the participants, twelve elderly subjects, six of them female (72·2 (SD 5·7) years), were investigated. On three separate days, blood pressure (BP) and heart rate were measured following ingestion of 300 ml drinks containing: (1) CHO (75 g glucose and 93 g Polyjoule (CHO polymer) providing 2732 kJ (653 kcal)); (2) 88% fat (cream blended with milk providing 2732 kJ (653 kcal)); (3) water. Systolic BP decreased following the CHO drink (P,0·001) and the high-fat drink (P,0·001) but not water; there was no difference in the magnitude of the decrease between the CHO drink and the drink containing fat (13·4 v. 15·6 mmHg). However, the onset of the fall was slower after the fat-containing drink (13·0 v. 26·5 min (P¼0·01); area under the curve for 0–30 min for CHO drink 26·5 v. fat-containing drink 125·4mmHg £ min (P¼0·043)). We conclude that ingestion of a high-fat drink results in a comparable fall in BP to a CHO drink although the onset is relatively slower. These observations may have implications for the management of postprandial hypotension.
Keywords: postprandial hypotension; blood pressure; elderly
Provenance: Published online by Cambridge University Press 08 Mar 2007
Rights: © The Authors 2006
RMID: 0020060327
DOI: 10.1079/BJN20051633
Appears in Collections:Medicine publications

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