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|Title:||T-cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction|
|Citation:||Prostate, 2006; 66(6):578-590|
|Jason R. Lees, Bridget Charbonneau, John D. Hayball, Kerrilyn Diener, Michael Brown, Robert Matusik, Michael B. Cohen and Timothy L. Ratliff|
|Abstract:||METHODS The ability of CD8+ T-cells to induce prostate inflammation was examined using a prostate ovalbumin expressing transgenic mouse (POET) and/or adoptive transfer of T-cell receptor (TCR) transgenic T-cells (OT-I) that specifically recognize ovalbumin. Localization of inflammatory cells to prostate tissue was examined following T-cell activation via endogenous prostatic antigen, recombinant type 5 adenovirus carrying the gene coding ovalbumin (Ad5-mOVA), or adoptive transfer of in vitro antigen stimulated OT-I cells. RESULTS Ovalbumin specific OT-I cells were activated by autologous prostate antigen and trafficked to the prostate, but did not induce inflammation unless present in overwhelming numbers (65% of CD8+ T-cells). Activation of antigen specific CD8+ T-cells in vitro (peptide pulsed antigen presenting cells) or in vivo (Ad5-mOVA) induced transitory prostate inflammation, without induction of prostate pathology, regardless of CD4+ T-cell availability. Inflammation also was observed in OT-I × POET mice but again, pathological effects were not observed. CONCLUSIONS T lymphocytes specific for a prostate antigen are capable of inducing inflammatory infiltration of prostatic tissue rapidly following activation, but do not produce pathological prostate injury.|
|Keywords:||prostate inflammation; tissue specific antigen; cytotoxic T lymphocytes; tolerance|
|Description:||Copyright © 2005 Wiley-Liss, Inc.|
|Appears in Collections:||Medicine publications|
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