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Type: Journal article
Title: Common chromosomal fragile sites and cancer: Focus on FRA16D
Author: O'Keefe, L.
Richards, R.
Citation: Cancer Letters, 2006; 232(1):37-47
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2006
ISSN: 0304-3835
Organisation: Centre for the Molecular Genetics of Development
Statement of
Louise V. O'Keefe and Robert I. Richards
Abstract: A growing body of experimental evidence supports the view that certain human chromosomal fragile sites have roles to play in cancer. The principle lines of evidence are at the level of mutation mechanism and gene function. Most research in this area has previously focussed on the FRA3B common fragile site and the FHIT gene that spans this site. Here we review recent progress in characterising the second most readily observed common fragile site, FRA16D, and the WWOX gene that spans it. Comparative analyses of FRA3B/FHIT and FRA16D/WWOX reveal some striking similarities suggesting that these sites and their associated genes may play a part in a normal protective response of cells to environmental stress.
Keywords: Common chromosomal fragile site; In vitro fragility/in vivo instability; Protective gene function
RMID: 0020060069
DOI: 10.1016/j.canlet.2005.07.041
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Appears in Collections:Molecular and Biomedical Science publications
Centre for the Molecular Genetics of Development publications

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