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https://hdl.handle.net/2440/23981
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dc.contributor.author | Gentili, S. | - |
dc.contributor.author | Waters, M. | - |
dc.contributor.author | McMillen, I. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2006; 290(4):R1044-R1051 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/23981 | - |
dc.description.abstract | It is unknown whether the JAK/STAT/suppressor of cytokine signaling-3 (SOCS-3) intracellular signaling pathway plays a role in tissue growth and metabolism during fetal life. We investigated whether there is a differential profile of SOCS-3 expression in the liver and perirenal adipose tissue during the period of increased fetal growth in late gestation and the impact of fetal growth restriction on SOCS-3 expression in the fetal liver. We also determined whether basal SOCS-3 expression in the fetal liver and perirenal adipose tissue is regulated by endogenous fetal prolactin (PRL). SOCS-3 mRNA abundance was higher in the liver than in the pancreas, spleen, and kidney of the sheep fetus during late gestation. In the liver, SOCS-3 mRNA expression was increased (P < 0.05) between 125 (n = 4) and 145 days (n = 7) gestation and lower (P < 0.05) in growth-restricted compared with normally grown fetal sheep in late gestation. The relative expression of SOCS-3 mRNA in the fetal liver was directly related to the mean plasma PRL concentrations during a 48-h infusion of either a dopaminergic agonist, bromocriptine (n = 7), or saline (n = 5), such that SOCS-3 mRNA expression was lower when plasma PRL concentrations decreased below approximately 20 ng/ml [y = 0.99 - (2.47/x) + (4.96/x(2)); r(2) = 0.91, P < 0.0001, n = 12]. No relationship was shown between the abundance of phospho-STAT5 in the fetal liver and circulating PRL. SOCS-3 expression in perirenal adipose tissue decreased (P < 0001) between 90-91 (n = 6) and 140-145 days (n = 9) gestation and was not related to endogenous PRL concentrations. Thus SOCS-3 is differentially expressed and regulated in key fetal tissues and may play an important and tissue-specific role in the regulation of cellular proliferation and differentiation before birth. | - |
dc.language.iso | en | - |
dc.publisher | Amer Physiological Soc | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpregu.00573.2005 | - |
dc.subject | Liver | - |
dc.subject | Adipose Tissue | - |
dc.subject | Placenta | - |
dc.subject | Animals | - |
dc.subject | Sheep | - |
dc.subject | Bromocriptine | - |
dc.subject | Prolactin | - |
dc.subject | RNA, Messenger | - |
dc.subject | Signal Transduction | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Gestational Age | - |
dc.subject | STAT5 Transcription Factor | - |
dc.subject | Suppressor of Cytokine Signaling Proteins | - |
dc.subject | Suppressor of Cytokine Signaling 3 Protein | - |
dc.title | Differential regulation of suppressor of cytokine signaling-3 in the liver and adipose tissue of the sheep fetus in late gestation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.00573.2005 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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