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dc.contributor.authorPalaniappan, R.-
dc.contributor.authorSingh, S.-
dc.contributor.authorSingh, U.-
dc.contributor.authorSakthivel, S.-
dc.contributor.authorAdes, E.-
dc.contributor.authorBriles, D.-
dc.contributor.authorHollingshead, S.-
dc.contributor.authorPaton, J.-
dc.contributor.authorSampson, J.-
dc.contributor.authorLillard Jr., J.-
dc.identifier.citationInfection and Immunity, 2005; 73(2):1006-1013-
dc.descriptionCopyright © 2005, American Society for Microbiology-
dc.description.abstractLarger numbers of pneumococci were detected in the nasal tract compared to the lung, cervical lymph nodes, and spleen 1, 2, 4, 7, 14, and 21 days after nasal challenge with Streptococcus pneumoniae strain EF3030. In this mouse model of pneumococcal carriage, peripheral S. pneumoniae pneumococcal surface adhesin A (PsaA)-specific humoral responses (immunoglobulin G2a [IgG2a] IgG1 = IgG2b > IgG3) were significantly higher than pneumococcal surface protein A (PspA)-specific, genetic toxoid derivative of pneumolysin (PdB)-specific, or pneumococcal surface protein C (PspC)-specific serum antibody levels. However, PspA-specific mucosal IgA antibody levels were significantly higher than those against PsaA, PdB, and PspC. In general, both PsaA- and PspA-specific lung-, cervical lymph node-, nasal tract-, and spleen-derived CD4+ T-cell cytokine (interleukin-4, interleukin-6, granulocyte-macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha) and proliferative responses were higher than those for either PspC or PdB. Taken together, these findings suggest that PsaA- and PspA-specific mucosal responses as well as systemic humoral and T helper cell cytokine responses are predominantly yet differentially induced during pneumococcal carriage.-
dc.description.statementofresponsibilityRavichandran Palaniappan, Shailesh Singh, Udai P. Singh, Senthil Kumar K. Sakthivel, Edwin W. Ades, David E. Briles, Susan K. Hollingshead, James C. Paton, Jacquelyn S. Sampson, and James W. Lillard, Jr.-
dc.publisherAmer Soc Microbiology-
dc.subjectT-Lymphocyte Subsets-
dc.subjectCD4-Positive T-Lymphocytes-
dc.subjectPneumococcal Infections-
dc.subjectDisease Models, Animal-
dc.subjectBacterial Proteins-
dc.subjectAdhesins, Bacterial-
dc.subjectMembrane Transport Proteins-
dc.subjectAntigens, Bacterial-
dc.subjectCell Division-
dc.titleDifferential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage-
dc.typeJournal article-
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]-
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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