Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage
Author: Palaniappan, R.
Singh, S.
Singh, U.
Sakthivel, S.
Ades, E.
Briles, D.
Hollingshead, S.
Paton, J.
Sampson, J.
Lillard Jr., J.
Citation: Infection and Immunity, 2005; 73(2):1006-1013
Publisher: Amer Soc Microbiology
Issue Date: 2005
ISSN: 0019-9567
Statement of
Ravichandran Palaniappan, Shailesh Singh, Udai P. Singh, Senthil Kumar K. Sakthivel, Edwin W. Ades, David E. Briles, Susan K. Hollingshead, James C. Paton, Jacquelyn S. Sampson, and James W. Lillard, Jr.
Abstract: Larger numbers of pneumococci were detected in the nasal tract compared to the lung, cervical lymph nodes, and spleen 1, 2, 4, 7, 14, and 21 days after nasal challenge with Streptococcus pneumoniae strain EF3030. In this mouse model of pneumococcal carriage, peripheral S. pneumoniae pneumococcal surface adhesin A (PsaA)-specific humoral responses (immunoglobulin G2a [IgG2a] IgG1 = IgG2b > IgG3) were significantly higher than pneumococcal surface protein A (PspA)-specific, genetic toxoid derivative of pneumolysin (PdB)-specific, or pneumococcal surface protein C (PspC)-specific serum antibody levels. However, PspA-specific mucosal IgA antibody levels were significantly higher than those against PsaA, PdB, and PspC. In general, both PsaA- and PspA-specific lung-, cervical lymph node-, nasal tract-, and spleen-derived CD4+ T-cell cytokine (interleukin-4, interleukin-6, granulocyte-macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha) and proliferative responses were higher than those for either PspC or PdB. Taken together, these findings suggest that PsaA- and PspA-specific mucosal responses as well as systemic humoral and T helper cell cytokine responses are predominantly yet differentially induced during pneumococcal carriage.
Keywords: T-Lymphocyte Subsets
CD4-Positive T-Lymphocytes
Pneumococcal Infections
Disease Models, Animal
Bacterial Proteins
Adhesins, Bacterial
Membrane Transport Proteins
Antigens, Bacterial
Cell Division
Description: Copyright © 2005, American Society for Microbiology
DOI: 10.1128/IAI.73.2.1006-1013.2005
Published version:
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.