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Type: Journal article
Title: Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats
Author: Toden, S.
Bird, A.
Topping, D.
Conlon, M.
Citation: Nutrition and Cancer: an international journal, 2005; 51(1):45-51
Publisher: Lawrence Erlbaum Assoc Inc
Issue Date: 2005
ISSN: 0163-5581
Statement of
Shusuke Toden, Anthony R. Bird, David L. Topping, and Michael A. Conlon
Abstract: Epidemiologic studies suggest that dietary complex carbohydrates are protective against colorectal cancer but dietary protein may increase risk. However, experimental data to support these relationships are scant. We have shown in rats that consumption of a high-protein (25% casein) diet for 4 wk resulted in a twofold increase in damage to colonocyte DNA compared with a low-protein (15% casein) diet. This was associated with thinning of the colonic mucous barrier and increased levels of fecal p-cresol. Addition of resistant starch as a high-amylose maize starch to the diet increased cecal short-chain fatty acid pools and attenuated DNA damage, suggesting protection against genotoxic agents. In humans, this could translate to altered risk of colonic cancer.
Keywords: Intestinal Mucosa
Rats, Sprague-Dawley
DNA Damage
Fatty Acids, Volatile
Dietary Proteins
Comet Assay
Random Allocation
Cell Division
Rights: © 2005, Lawrence Erlbaum Associates, Inc.
DOI: 10.1207/s15327914nc5101_7
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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