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Type: Journal article
Title: Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep
Author: Morrison, J.
Rurak, D.
Chien, C.
Kennaway, D.
Gruber, N.
McMillen, I.
Riggs, K.
Citation: Reproductive Sciences, 2005; 12(5):356-364
Publisher: Elsevier Science Inc
Issue Date: 2005
ISSN: 1071-5576
Statement of
Janna L. Morrison, Dan W. Rurak, Caly Chien, David J. Kennaway, Nancy Gruber, I. Caroline McMillen, and K. Wayne Riggs
Abstract: <h4>Objective</h4>Depression during pregnancy is frequently treated with the selective serotonin reuptake inhibitor (SSRI), fluoxetine (FX), commonly known as Prozac (Eli Lilly & Co, Indianapolis, IN). FX potentiates serotoninergic neurotransmission and serotonin has been implicated in the regulation of circadian rhythms. We have therefore investigated the effect of chronic administration of FX on maternal and fetal circadian rhythms in sheep.<h4>Methods</h4>Following an initial bolus dose of 70 mg FX, an 8-day continuous infusion of FX (n = 11, 98.5 microg/kg x d) was performed. Controls (n = 13) were treated with sterile water vehicle only. Maternal and fetal plasma melatonin and prolactin concentrations were determined every 3 hours for 24 hours and then every 6 hours for 24 hours beginning on the fourth day of infusion.<h4>Results</h4>FX treatment did not alter either the basal or circadian rhythms of either maternal or fetal plasma melatonin and prolactin concentrations. Fetal cardiovascular and behavioral state parameters were measured continuously. While the incidence of low-voltage (LV) electrocortical (ECOG) activity was significantly reduced in fetuses in the FX group, there was no effect of FX on the diurnal rhythms in fetal arterial pressure, heart rate, breathing movements, or behavioral state.<h4>Conclusion</h4>These results show that maternal FX treatment does not result in significant alterations in maternal and fetal hormonal and behavioral circadian rhythms.
Keywords: Animals
Serotonin Uptake Inhibitors
Infusions, Intravenous
Injections, Intravenous
Circadian Rhythm
Maternal-Fetal Exchange
Pregnancy, Animal
Blood Pressure
Heart Rate
Provenance: The Journal of the Society for Gynecologic Investigation is no longer published by Elsevier (as of December 31, 2006). Journal of the Society for Gynecologic Investigation will continue being published by Sage Publications, under the new title Reproductive Sciences
Rights: © 2005 SAGE Publications
DOI: 10.1016/j.jsgi.2005.03.001
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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