Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/27546
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Type: Journal article
Title: The effects of salmon calcitonin-induced hypocalcemia on bone metabolism in ovariectomized rats
Author: Davey, R.
Morris, H.
Citation: Journal of Bone and Mineral Metabolism, 2005; 23(5):359-365
Publisher: Springer-Verlag Tokyo
Issue Date: 2005
ISSN: 0914-8779
1435-5604
Abstract: The ovariectomized rat has proved to be a most useful model for preclinical testing of potential therapies for osteoporosis. We describe the immediate effects of a single treatment with salmon calcitonin (sCT) on calcium homeostasis and bone turnover markers in 6-month-old sham and ovariectomized (ovx) rats at 15 days postovariectomy. Rats were fasted for 24 h prior to and following administration of 0.3 microg/kg body weight sCT. Blood specimens were collected at 0 (pretreatment), 2, 4, and 8 h. Urine samples were collected during the intervening periods. sCT treatment produced a decrease in blood ionized calcium at 2 h posttreatment in sham and ovx rats (P < 0.001), which was exaggerated in the ovx rats (P < 0.001). Increased parathyroid hormone (PTH) levels (P < 0.001) accompanied the hypocalcemia in ovx rats. Furthermore, PTH levels were significantly higher in ovx rats compared with sham rats for the same ionized calcium range of 1.275-1.300 mmol/l (P < 0.05). sCT treatment in sham rats increased urine hydroxyproline (UHyp) at 6 h posttreatment (P < 0.01). In conclusion, the calcitonin-induced hypocalcemia and secondary hyperparathyroidism was more pronounced in the ovariectomized rats, consistent with the actions of calcitonin in states of increased bone turnover induced by estrogen deficiency. This study highlights the importance of considering the actions of PTH and estrogen status when interpreting changes in calcium homeostasis and bone turnover following treatment with calcitonin in rodent models and provides further evidence for a potential role of estrogen in parathyroid function.
Keywords: Bone and Bones
Animals
Rats
Rats, Sprague-Dawley
Hypocalcemia
Body Weight
Calcium
Calcitonin
Parathyroid Hormone
Hydroxyproline
Estrogens
Ovariectomy
Homeostasis
Time Factors
Female
DOI: 10.1007/s00774-005-0613-8
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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