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Type: Journal article
Title: Functional alignment of regulatory networks: a study of temperate phages
Author: Trusina, A.
Sneppen, K.
Dodd, I.
Shearwin, K.
Egan, J.
Citation: PLoS Computational Biology, 2005; 1(7):599-633
Publisher: Public Library of Science
Issue Date: 2005
ISSN: 1553-7358
Statement of
Ala Trusina, Kim Sneppen, Ian B. Dodd, Keith E. Shearwin, J. Barry Egan
Abstract: The relationship between the design and functionality of molecular networks is now a key issue in biology. Comparison of regulatory networks performing similar tasks can provide insights into how network architecture is constrained by the functions it directs. Here, we discuss methods of network comparison based on network architecture and signaling logic. Introducing local and global signaling scores for the difference between two networks, we quantify similarities between evolutionarily closely and distantly related bacteriophages. Despite the large evolutionary separation between phage λ and 186, their networks are found to be similar when difference is measured in terms of global signaling. We finally discuss how network alignment can be used to pinpoint protein similarities viewed from the network perspective.
Keywords: Bacteriophages
Signal Transduction
Gene Expression Regulation, Viral
Models, Biological
Molecular Sequence Data
Rights: Copyright: © 2005 Trusina et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pcbi.0010074
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Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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