Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/27595
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Type: Journal article
Title: Functional alignment of regulatory networks: a study of temperate phages
Author: Trusina, A.
Sneppen, K.
Dodd, I.
Shearwin, K.
Egan, J.
Citation: PLoS Computational Biology, 2005; 1(7):599-633
Publisher: Public Library of Science
Issue Date: 2005
ISSN: 1553-7358
1553-734X
Statement of
Responsibility: 
Ala Trusina, Kim Sneppen, Ian B. Dodd, Keith E. Shearwin, J. Barry Egan
Abstract: The relationship between the design and functionality of molecular networks is now a key issue in biology. Comparison of regulatory networks performing similar tasks can provide insights into how network architecture is constrained by the functions it directs. Here, we discuss methods of network comparison based on network architecture and signaling logic. Introducing local and global signaling scores for the difference between two networks, we quantify similarities between evolutionarily closely and distantly related bacteriophages. Despite the large evolutionary separation between phage λ and 186, their networks are found to be similar when difference is measured in terms of global signaling. We finally discuss how network alignment can be used to pinpoint protein similarities viewed from the network perspective.
Keywords: Bacteriophages; Phylogeny; Signal Transduction; Gene Expression Regulation, Viral; Models, Biological; Molecular Sequence Data
Rights: Copyright: © 2005 Trusina et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020051963
DOI: 10.1371/journal.pcbi.0010074
Appears in Collections:Molecular and Biomedical Science publications

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