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Type: Journal article
Title: 2D versus 3D radiation therapy for prostate carcinoma: A direct comparison of dose volume parameters
Author: Sale, C.
Yeoh, E.
Scutter, S.
Bezak, E.
Citation: Acta Oncologica, 2005; 44(4):348-354
Publisher: Taylor & Francis As
Issue Date: 2005
ISSN: 0284-186X
Statement of
Charlotte A. Sale, Eric E. K. Yeoh, Sheila Scutter and Eva Bezak
Abstract: That three dimensional (3D) planning for radiation therapy (RT) of carcinoma of the prostate (CaP) improves radiation dosimetry to the tumour and reduces dose to the rectum and bladder compared with 2D planning, has not been properly evaluated. We addressed this by downloading the CT data files of twenty-two patients who had completed 2D planned RT for CaP onto a 3D planning system and re-planning RT using the same four field technique and dose prescription as the 2D technique. The radiation dose at 100%, 90%, 50% and 0% volumes (D100, D90, D50 and D0) of the Dose Volume Histograms (DVH's) of the GTV, PTV, rectum and bladder, the area under the curves of each DVH and the field sizes were evaluated and compared between the two sets of plans. Repeated measured t-tests were used to compare the means of the different measurements. The D100, D90 and D50 of the GTV, PTV and rectum were increased for the 3D versus the 2D plans (p < 0.05 for each parameter). The area under the rectal DVH was also greater for the 3D plans (p < 0.05). These changes are attributable to the larger field sizes, particularly the length in the 3D compared with the 2D plans.
Keywords: Rectum; Humans; Prostatic Neoplasms; Neoplasm Staging; Treatment Outcome; Radiotherapy, Conformal; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Area Under Curve; Dose-Response Relationship, Radiation; Aged; Male; Urinary Bladder
Rights: © 2005 Taylor & Francis
RMID: 0020050834
DOI: 10.1080/02841860510029815
Appears in Collections:Chemistry and Physics publications

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