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|Title:||Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development|
Mattick, John S.
Wood, Stephen Andrew
|Citation:||Mechanisms of Development, 2000; 91(1-2):383-386|
|School/Discipline:||School of Molecular and Biomedical Science|
|Organisation:||Centre for the Molecular Genetics of Development|
|Abstract:||The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053–1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina.|
|Keywords:||FAM; De-ubiquitinating enzyme; AF-6; Canoe; Ras-binding protein; Retinal pigment epithelium; Lens epithelium; Corneal epithelium|
|Appears in Collections:||Centre for the Molecular Genetics of Development publications|
Molecular and Biomedical Science publications
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