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DC Field | Value | Language |
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dc.contributor.author | Kanai-Azuma, Masami | en |
dc.contributor.author | Mattick, John S. | en |
dc.contributor.author | Kaibuchi, Kozo | en |
dc.contributor.author | Wood, Stephen Andrew | en |
dc.date.issued | 2000 | en |
dc.identifier.citation | Mechanisms of Development, 2000; 91(1-2):383-386 | en |
dc.identifier.issn | 0925-4773 | en |
dc.identifier.uri | http://hdl.handle.net/2440/28008 | - |
dc.description.abstract | The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053–1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. | en |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/506090/description#description | en |
dc.language.iso | en | en |
dc.publisher | Elsevier Science | en |
dc.subject | FAM; De-ubiquitinating enzyme; AF-6; Canoe; Ras-binding protein; Retinal pigment epithelium; Lens epithelium; Corneal epithelium | en |
dc.title | Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development | en |
dc.type | Journal article | en |
dc.contributor.school | School of Molecular and Biomedical Science | en |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | en |
dc.identifier.doi | 10.1016/S0925-4773(99)00294-4 | en |
Appears in Collections: | Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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