Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/28012
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dc.contributor.authorKaram, S.-
dc.contributor.authorBurrows, R.-
dc.contributor.authorLogan, C.-
dc.contributor.authorKoblar, S.-
dc.contributor.authorPasquale, E.-
dc.contributor.authorBothwell, M.-
dc.date.issued2000-
dc.identifier.citationThe Journal of Neuroscience, 2000; 20(17):6488-6500-
dc.identifier.issn0270-6474-
dc.identifier.issn1529-2401-
dc.identifier.urihttp://hdl.handle.net/2440/28012-
dc.description.abstractSpatiotemporal expression patterns of six members of the Eph gene family (EphA4, EphA3, EphB2, ephrin-B1, ephrin-A2, and ephrin-A5) were characterized immunocytochemically at various stages of chick cerebellar development. EphA4 expression is observed in the cerebellar anlage as early as embryonic day 5 (E5) and continues in the posthatch cerebellum. During the early period of cerebellar development (E3-E8), complementarity is observed between EphA4 and ephrin-A5 expression within the cerebellar-isthmal region. By E8, differential expression of EphA4 in parasagittal Purkinje cell bands is evident, and the expression remains banded in the posthatch cerebellum. Banded expression of the ephrin-A5 ligand complements EphA4 expression during the middle period (E9-E15). During this period, ephrin-A2 and EphA3 are coexpressed in a banded pattern and with variable correlation to EphA4. Variability in the banding expression is observed for EphA4, EphA3, ephrin-A5, and ephrin-A2 across different lobes, and graded complementarity in the expression pattern of EphA3 and ephrin-A5 is observed in the external granular layer between the posterior and anterior lobes. Analysis of Purkinje cell birth date in correlation with Eph-ephrin expression during the middle period reveals that early-born cells express EphA4, whereas late-born cells express ephrin-A5. Finally, EphA4 expression domains are respected by migrating granule cell ribbons, which express both ephrin-B1 and EphB2. These expression patterns suggest multiple roles for the Eph-ephrin system in cerebellar development, including demarcation/enforcement of boundaries of the cerebellar anlage, formation/maintenance of Purkinje cell compartments, and restriction of the early phase of granule cell migration to ribbons.-
dc.language.isoen-
dc.publisherSoc Neuroscience-
dc.source.urihttp://www.jneurosci.org/cgi/content/abstract/20/17/6488-
dc.subjectPurkinje cell-
dc.titleEph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration-
dc.typeJournal article-
dc.contributor.organisationCentre for the Molecular Genetics of Development-
dc.identifier.doi10.1523/jneurosci.20-17-06488.2000-
pubs.publication-statusPublished-
dc.identifier.orcidKoblar, S. [0000-0002-8667-203X]-
Appears in Collections:Aurora harvest 6
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications

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