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https://hdl.handle.net/2440/28028
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Type: | Journal article |
Title: | Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae |
Author: | Ogunniyi, A. Folland, R. Briles, D. Hollingshead, S. Paton, J. |
Citation: | Infection and Immunity, 2000; 68(5):3028-3033 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2000 |
ISSN: | 0019-9567 1098-5522 |
Editor: | Tuomanen, E.I. |
Abstract: | The vaccine potential of a combination of three pneumococcal virulence proteins was evaluated in an active-immunization-intraperitoneal-challenge model in BALB/c mice, using very high challenge doses of Streptococcus pneumoniae. The proteins evaluated were a genetic toxoid derivative of pneumolysin (PdB), pneumococcal surface protein A (PspA), and a 37-kDa metal-binding lipoprotein referred to as PsaA. Mice immunized with individual proteins or combinations thereof were challenged with high doses of virulent type 2 or type 4 pneumococci. The median survival times for mice immunized with combinations of proteins, particularly PdB and PspA, were significantly longer than those for mice immunized with any of the antigens alone. A similar effect was seen in a passive protection model. Thus, combinations of pneumococcal proteins may provide the best non-serotype-dependent protection against S. pneumoniae. |
Keywords: | Animals Mice, Inbred BALB C Mice Streptococcus pneumoniae Pneumococcal Infections Lipoproteins Bacterial Proteins Adhesins, Bacterial Carrier Proteins Membrane Transport Proteins Recombinant Fusion Proteins Streptolysins Antibodies, Bacterial Antigens, Bacterial Immunization, Passive Vaccination Virulence Male |
DOI: | 10.1128/IAI.68.5.3028-3033.2000 |
Published version: | http://dx.doi.org/10.1128/iai.68.5.3028-3033.2000 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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