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Type: Journal article
Title: Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae
Author: Ogunniyi, A.
Folland, R.
Briles, D.
Hollingshead, S.
Paton, J.
Citation: Infection and Immunity, 2000; 68(5):3028-3033
Publisher: Amer Soc Microbiology
Issue Date: 2000
ISSN: 0019-9567
Abstract: The vaccine potential of a combination of three pneumococcal virulence proteins was evaluated in an active-immunization-intraperitoneal-challenge model in BALB/c mice, using very high challenge doses of Streptococcus pneumoniae. The proteins evaluated were a genetic toxoid derivative of pneumolysin (PdB), pneumococcal surface protein A (PspA), and a 37-kDa metal-binding lipoprotein referred to as PsaA. Mice immunized with individual proteins or combinations thereof were challenged with high doses of virulent type 2 or type 4 pneumococci. The median survival times for mice immunized with combinations of proteins, particularly PdB and PspA, were significantly longer than those for mice immunized with any of the antigens alone. A similar effect was seen in a passive protection model. Thus, combinations of pneumococcal proteins may provide the best non-serotype-dependent protection against S. pneumoniae.
Keywords: Animals; Mice, Inbred BALB C; Mice; Streptococcus pneumoniae; Pneumococcal Infections; Lipoproteins; Bacterial Proteins; Adhesins, Bacterial; Carrier Proteins; Membrane Transport Proteins; Recombinant Fusion Proteins; Streptolysins; Antibodies, Bacterial; Antigens, Bacterial; Immunization, Passive; Vaccination; Virulence; Male
RMID: 0001002105
DOI: 10.1128/IAI.68.5.3028-3033.2000
Appears in Collections:Molecular and Biomedical Science publications

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