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Type: Journal article
Title: Evolutionary analysis of vertebrate Notch genes
Author: Kortschak, R.
Tamme, R.
Lardelli, M.
Citation: Development, Genes and Evolution, 2001; 211(7):350-354
Publisher: Springer-Verlag
Issue Date: 2001
ISSN: 0949-944X
Organisation: Centre for the Molecular Genetics of Development
Statement of
Daniel R. Kortschak, Richard Tamme and Michael Lardelli
Abstract: We have conducted an evolutionary analysis of Notch genes of the vertebrates Danio rerio and Mus musculus to examine the expansion and diversification of the Notch family during vertebrate evolution. The existence of multiple Notch genes in vertebrate genomes suggests that the increase in Notch signaling pathways may be necessary for the additional complexity observed in the vertebrate body plan. However, orthology relationships within the vertebrate Notch family indicate that biological functions are not fixed within orthologous groups. Phylogenetic reconstruction of the vertebrate Notch family suggests that the zebrafish notch1a and 1b genes resulted from a duplication occurring around the time of the teleost/mammalian divergence. There is also evidence that the mouse Notch4 gene is the result of a rapid divergence from a Notch3-like gene. Investigation of the ankyrin repeat region sequences showed there to be little evidence for gene conversion events between repeat units. However, relationships between repeats 2–5 suggest that these repeats are the result of a tandem duplication of a dual repeat unit. Selective pressure on maintenance of ankyrin repeat sequences indicated by relationships between the repeats suggests that specific repeats are responsible for particular biological activities, a finding consistent with mutational studies of the Caenorhabditis elegans gene glp-1. Sequence similarities between the ankyrin repeats and the region immediately C-terminal of the repeats further suggests that this region may be involved in the modulation of ankyrin repeat function.
Keywords: Animals
Membrane Proteins
Evolution, Molecular
Amino Acid Sequence
Ankyrin Repeat
Sequence Homology, Amino Acid
Molecular Sequence Data
Receptors, Notch
Description: The original publication can be found at
Provenance: An erratum for this article has been published. Please click on the description link below to view the erratum.
DOI: 10.1007/s004270100159
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Appears in Collections:Aurora harvest 2
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications

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