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Type: Journal article
Title: Fragile and unstable chromosomes in cancer: causes and consequences
Author: Richards, R.
Citation: Trends in Genetics, 2001; 17(6):339-345
Publisher: Elsevier Science London
Issue Date: 2001
ISSN: 0168-9525
Abstract: Cancer cells commonly exhibit various forms of genetic instability, such as changes in chromosome copy number, translocations and point mutations in particular genes. Although transmissible change seems to be an essential part of the neoplastic process, the extent to which DNA instability is a cause rather than a consequence of cancer is unclear. Chromosomal fragile sites have been proposed to be not only susceptible to DNA instability in cancer cells, but also associated with genes that contribute to the neoplastic process. Mutation at fragile site loci might therefore have a causative role in cancer. Recent studies on one class of human chromosomal fragile sites show that instability at fragile site loci can functionally contribute to tumor cell biology.
Keywords: Chromosomes, Human; Animals; Humans; Neoplasms; Cell Transformation, Neoplastic; Chromosome Fragility; Chromosome Mapping; Mutation; Chromosome Fragile Sites
RMID: 0020011380
DOI: 10.1016/S0168-9525(01)02303-4
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Appears in Collections:Molecular and Biomedical Science publications

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