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https://hdl.handle.net/2440/28169
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Type: | Journal article |
Title: | Localized expression of a dpp/BMP2/4 ortholog in a coral embryo |
Author: | Hayward, D. Samuel, G. Pontynen, P. Catmull, J. Saint, R. Miller, D. Ball, E. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2002; 99(12):8106-8111 |
Publisher: | Natl Acad Sciences |
Issue Date: | 2002 |
ISSN: | 0027-8424 1091-6490 |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | David C. Hayward, Gabrielle Samuel, Patricia C. Pontynen, Julian Catmull, Robert Saint, David J. Miller, and Eldon E. Ball |
Abstract: | As the closest outgroup to the Bilateria, the Phylum Cnidaria is likely to be critical to understanding the origins and evolution of body axes. Proteins of the decapentaplegic (DPP)/bone morphogenetic protein (BMP) 2/4 subfamily are central to the specification of the dorsoventral (D/V) axis in bilateral animals, albeit with an axis inversion between arthropods and chordates. We show that a dpp/BMP2/4 ortholog (bmp2/4-Am) is present in the reef-building scleractinian coral, Acropora millepora (Class Anthozoa) and that it is capable of causing phenotypic effects in Drosophila that mimic those of the endogenous dpp gene. We also show that, during coral embryonic development, bmp2/4-Am expression is localized in an ectodermal region adjacent to the blastopore. Thus, a representative of the DPP/BMP2/4 subfamily of ligands was present in the common ancestor of diploblastic and triploblastic animals where it was probably expressed in a localized fashion during development. A localized source of DPP/BMP2/4 may have already been used in axis formation in this ancestor, or it may have provided a means by which an axis could evolve in triploblastic animals. |
Keywords: | Embryo, Nonmammalian Animals Cnidaria Transforming Growth Factor beta Drosophila Proteins Bone Morphogenetic Proteins Sequence Alignment Phylogeny Gene Expression Regulation, Developmental Amino Acid Sequence Sequence Homology, Amino Acid Molecular Sequence Data Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 |
DOI: | 10.1073/pnas.112021499 |
Published version: | http://www.pnas.org/content/99/12/8106.abstract |
Appears in Collections: | Aurora harvest 2 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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