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|Title:||Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2|
Mc Carty, R.
|Citation:||Development Genes and Evolution, 2002; 212(10):486-490|
|Organisation:||Centre for the Molecular Genetics of Development|
|Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli|
|Abstract:||Presenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.|
|Keywords:||Presenilin; Neural crest; Zebrafish; Alzheimer’s disease; Melanocyte|
|Description:||© Springer-Verlag 2002 The original publication can be found at www.springerlink.com|
|Appears in Collections:||Molecular and Biomedical Science publications|
Centre for the Molecular Genetics of Development publications
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