Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/28202
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Type: Journal article
Title: Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2
Author: Groth, C.
Nornes, S.
Mc Carty, R.
Tamme, R.
Lardelli, M.
Citation: Development Genes and Evolution, 2002; 212(10):486-490
Publisher: Springer
Issue Date: 2002
ISSN: 0949-944X
1432-041X
Organisation: Centre for the Molecular Genetics of Development
Statement of
Responsibility: 
Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli
Abstract: Presenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
Keywords: Presenilin; Neural crest; Zebrafish; Alzheimer’s disease; Melanocyte
Description: © Springer-Verlag 2002 The original publication can be found at www.springerlink.com
RMID: 0020021718
DOI: 10.1007/s00427-002-0269-5
Published version: http://www.springerlink.com/content/pne2xqatmd1kjga5/
Appears in Collections:Molecular and Biomedical Science publications
Centre for the Molecular Genetics of Development publications

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