Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2|
Mc Carty, R.
|Citation:||Development, Genes and Evolution, 2002; 212(10):486-490|
|Organisation:||Centre for the Molecular Genetics of Development|
|Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli|
|Abstract:||Presenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.|
|Description:||© Springer-Verlag 2002 The original publication can be found at www.springerlink.com|
|Appears in Collections:||Aurora harvest 2|
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.