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Type: Conference paper
Title: Modeling the effect of p53 on tumor heterogeneity and the mutator phenotype
Author: Ryan, M.
Berryman, M.
Abbott, D.
Citation: Biomedical applications of micro- and nanoengineering II : 13-15 December 2004, Sydney, Australia / Dan. V. Nicolau (ed.), pp. 144-152
Publisher: SPIE
Publisher Place: Bellingham, Washington
Issue Date: 2005
Series/Report no.: Proceedings of SPIE--the International Society for Optical Engineering ; 5651.
ISBN: 081945611X
ISSN: 1605-7422
Conference Name: Biomedical Applications of Micro- and Nanoengineering (2nd : 2004 : Sydney, Australia)
Editor: Nicolau, D.
Statement of
Melissa Ryan, Matthew J. Berryman, and Derek Abbott
Abstract: p53 is an important gene, involved in apoptosis (programmed celldeath), DNA repair, and cell cycle progression. We explore theselective advantages and disadvantages of mutations in the p53 geneon tumor cells, and the heterogeneity of tumor cell populations.Based on an evolutionary computational approach, our model considerschanges in mutation rate caused by lack of DNA repair processes, andthe lack of apoptosis caused by mutations in p53. We find that thedegree of robustness of p53 to mutations has a significant effect onthe tumor heterogeneity and "fitness", with clinical consequencesfor people who inherit p53 mutations.
Description: © 2005 COPYRIGHT SPIE--The International Society for Optical Engineering
DOI: 10.1117/12.602423
Appears in Collections:Aurora harvest 6
Electrical and Electronic Engineering publications

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