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Type: Conference paper
Title: In vitro osteosarcoma biosensing using THz time domain spectroscopy
Author: Ferguson, B.
Liu, H.
Hay, S.
Findlay, D.
Zhang, X.
Abbott, D.
Citation: BioMEMS and nanotechnology : 10-12 December 2003, Perth, Australia / Dan V. Nicolau, Uwe R. Muller, John M. Dell (eds.), pp. 304-316
Publisher: SPIE
Publisher Place: CD-ROM
Issue Date: 2004
Series/Report no.: Proceedings of SPIE--the International Society for Optical Engineering ; 5275.
ISBN: 0-8194-5168-1
ISSN: 0277-786X
Conference Name: Microelectronics, MEMS, and Nanotechnology 2003 (10 December 2003 : Perth, Australia)
Editor: Faraone, L.
Vardan, V.K.
Statement of
Bradley S. Ferguson, Haibo Liu, Shelley Hay, David Findlay, Xi-Cheng Zhang, and Derek Abbott
Abstract: Terahertz time domain spectroscopy (THz-TDS) has a wide range ofapplications from semiconductor diagnostics to biosensing. Recentattention has focused on bio-applications and several groups havenoted the ability of THz-TDS to differentiate basal cell carcinomatissue from healthy dermal tissue ex vivo.The contrast mechanism is unclear but has been attributed toincreased interstitial water in cancerous tissue. In this work weinvestigate the THz response of human osteosarcoma cells andnormal human bone cells grown in culture to isolate the cells'responses from other effects. A classification algorithms basedon a frequency selection by genetic algorithm is used to attemptto differentiate between the cell types based on the THz spectra.Encouraging preliminary results have been obtained.
Description: © 2004 COPYRIGHT SPIE--The International Society for Optical Engineering
DOI: 10.1117/12.527880
Appears in Collections:Aurora harvest 2
Orthopaedics and Trauma publications

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