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https://hdl.handle.net/2440/30498
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Type: | Book chapter |
Title: | Receptors for relaxin family peptides |
Author: | Bathgate, R. Ivell, R. Sanborn, B. Sherwood, O. Summers, R. |
Citation: | Relaxin and related peptides, 2005 / Sherwood, O., Fields, P., Steinetz, B. (ed./s), vol.1041, pp.61-76 |
Publisher: | New York Academy of Sciences |
Publisher Place: | New York, USA |
Issue Date: | 2005 |
Series/Report no.: | Annals of the New York Academy of Sciences ; v. 1041 |
ISBN: | 1573314854 |
Editor: | Sherwood, O. Fields, P. Steinetz, B. |
Abstract: | Recent studies have identified four receptors that are the physiological targets for relaxin family peptides. All are class I (rhodopsin like) G-protein-coupled receptors with LGR7 (RXFP1) and LGR8 (RXFP2) being type C leucine-rich repeat-containing receptors, whereas GPCR135 (RXFP3) and GPCR142 (RXFP4) resemble receptors that respond to small peptides such as somatostatin and angiotensin II. The cognate ligands for the receptors have been identified: relaxin for RXFP1; INSL3 for RXFP2; relaxin 3 for RXFP3 and INSL5 for RXFP4. RXFP1 and RXFP2 receptors produce increases in intracellular cAMP levels upon stimulation, although the response is complex and contains a component sensitive to PI-3-kinase inhibitors. There is also evidence that RXFP1 can activate Erk1/2 and nitric oxide synthase, and relaxin has been reported to enter cells and activate glucocorticoid receptors. In contrast, RXFP3 and RXFP4 couple to Gi by a pertussis toxin-sensitive mechanism to cause inhibition of cAMP production. Now that the receptors for relaxin family peptides and their cognate ligands have been identified, we suggest a nomenclature for both the peptides and the receptors that we hope will be helpful to researchers in this rapidly advancing field. |
Keywords: | Animals Humans Relaxin Receptors, G-Protein-Coupled Receptors, Peptide Ligands Signal Transduction Gene Expression |
DOI: | 10.1196/annals.1282.010 |
Published version: | http://dx.doi.org/10.1196/annals.1282.010 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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