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Type: Book chapter
Title: Receptors for relaxin family peptides
Author: Bathgate, R.
Ivell, R.
Sanborn, B.
Sherwood, O.
Summers, R.
Citation: Relaxin and related peptides, 2005 / Sherwood, O., Fields, P., Steinetz, B. (ed./s), vol.1041, pp.61-76
Publisher: New York Academy of Sciences
Publisher Place: New York, USA
Issue Date: 2005
Series/Report no.: Annals of the New York Academy of Sciences ; v. 1041
ISBN: 1573314854
Editor: Sherwood, O.
Fields, P.
Steinetz, B.
Abstract: Recent studies have identified four receptors that are the physiological targets for relaxin family peptides. All are class I (rhodopsin like) G-protein-coupled receptors with LGR7 (RXFP1) and LGR8 (RXFP2) being type C leucine-rich repeat-containing receptors, whereas GPCR135 (RXFP3) and GPCR142 (RXFP4) resemble receptors that respond to small peptides such as somatostatin and angiotensin II. The cognate ligands for the receptors have been identified: relaxin for RXFP1; INSL3 for RXFP2; relaxin 3 for RXFP3 and INSL5 for RXFP4. RXFP1 and RXFP2 receptors produce increases in intracellular cAMP levels upon stimulation, although the response is complex and contains a component sensitive to PI-3-kinase inhibitors. There is also evidence that RXFP1 can activate Erk1/2 and nitric oxide synthase, and relaxin has been reported to enter cells and activate glucocorticoid receptors. In contrast, RXFP3 and RXFP4 couple to Gi by a pertussis toxin-sensitive mechanism to cause inhibition of cAMP production. Now that the receptors for relaxin family peptides and their cognate ligands have been identified, we suggest a nomenclature for both the peptides and the receptors that we hope will be helpful to researchers in this rapidly advancing field.
Keywords: Animals
Receptors, G-Protein-Coupled
Receptors, Peptide
Signal Transduction
Gene Expression
DOI: 10.1196/annals.1282.010
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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