Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/3076
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dc.contributor.authorBelobrajdic, D.en
dc.contributor.authorMcIntosh, G.en
dc.contributor.authorOwens, J.en
dc.date.issued2004en
dc.identifier.citationJournal of Nutrition, 2004; 134(6):1454-1458en
dc.identifier.issn0022-3166en
dc.identifier.issn1541-6100en
dc.identifier.urihttp://hdl.handle.net/2440/3076-
dc.description© 2004 The American Society for Nutritional Sciencesen
dc.description.abstractA high-protein diet can reduce body weight and increase insulin sensitivity, but whether the type of dietary protein affects these outcomes is unknown. We hypothesized that feeding insulin-resistant rats a high-protein diet (32%) containing whey protein concentrate (WPC) would reduce body weight and tissue lipid levels and increase insulin sensitivity more than a diet containing red meat (RM). Rats were fed a high-fat diet (300 g fat/kg diet) for 9 wk, then switched to a diet containing either 80 or 320 g protein/kg diet, provided by either WPC or RM, for 6 wk (n = 8). The rats were then killed after overnight food deprivation. High dietary protein reduced energy intake (P < 0.001) and visceral (P < 0.001), subcutaneous (P < 0.001), and carcass fat (P < 0.05). Increasing the dietary density of WPC, but not of RM, reduced body weight gain by 4% (P < 0.001). Dietary WPC also reduced plasma insulin concentration by 40% (P < 0.05) and increased insulin sensitivity, compared to RM (P < 0.05). These findings support the conclusions that a high-protein diet reduces energy intake and adiposity and that whey protein is more effective than red meat in reducing body weight gain and increasing insulin sensitivity.en
dc.description.statementofresponsibilityDamien P. Belobrajdic, Graeme H. McIntosh, and Julie A. Owensen
dc.language.isoenen
dc.publisherAmer Inst Nutritionen
dc.source.urihttp://jn.nutrition.org/cgi/content/abstract/134/6/1454en
dc.subjectWhey protein; red meat; protein density; weight gain; insulin sensitivityen
dc.titleA high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in Wistar ratsen
dc.typeJournal articleen
dc.identifier.rmid0020040547en
dc.identifier.doi10.1093/jn/134.6.1454en
dc.identifier.pubid56954-
pubs.library.collectionMolecular and Biomedical Science publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]en
Appears in Collections:Molecular and Biomedical Science publications

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