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|Title:||Intestinal mycoplasma in Crohn's disease|
|Citation:||Inflammatory bowel disease: Crossroads of microbes, epithelium and immune systems, 2004 / Chadwick, D., Goode, J. (ed./s), pp.85-98|
|Publisher Place:||The Atrium, Southern Gate, Chichester PO19 8SQ, UK|
|Series/Report no.:||Novartis Foundation symposium ; 263|
|Abstract:||Intestinal diversion with reconnection in active Crohn's disease (CD) indicates that luminal contents or bacteria contribute to the formation of CD lesions. Fluorescent staining for mycoplasma in freshly resected Crohn's tissue and electron microscopy reveal intracellular organisms akin to mycoplasma. Historically, tissue culture of CD has shown mycoplasma described as contaminants. Mycoplasma are surface epithelial parasites requiring exogenous cholesterol for membrane stability and cell entry. PCR of intestinal tissue has shown Mycoplasma pneumoniae to be detectable more significantly in CD. Oral M. iowae in experimental poultry localizes to the distal small bowel and colon. Hypothetically, lipopeptides of mycoplasmal membranes are proposed to cause chronicity and stronger immune responses than by other bacteria. 'Intestinal' mycoplasmas, from a number of observations, deserve consideration as organisms mediating inflammation of acute and chronic CD.|
|Keywords:||Colon; Intestine, Small; Epithelial Cells; Animals; Humans; Mycoplasma; Crohn Disease; Peptides; DNA, Bacterial; Microscopy, Electron; Microscopy, Fluorescence; Polymerase Chain Reaction|
|Appears in Collections:||Surgery publications|
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