Adelaide Research & Scholarship
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https://hdl.handle.net/2440/3132
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| Type: | Journal article |
| Title: | Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy |
| Author: | Tan, N. Heron, S. Scheffer, I. Pelekanos, J. McMahon, J. Vears, D. Mulley, J. Berkovic, S. |
| Citation: | Neurology, 2004; 63(6):1090-1092 |
| Publisher: | Lippincott Williams & Wilkins |
| Issue Date: | 2004 |
| ISSN: | 0028-3878 1526-632X |
| Abstract: | Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance. |
| Keywords: | Hippocampus Epilepsy, Temporal Lobe Sclerosis Anticonvulsants Reproducibility of Results Amino Acid Substitution Drug Resistance, Multiple Gene Frequency Genotype Haplotypes Mutation, Missense Polymorphism, Genetic Polymorphism, Single Nucleotide Alleles Exons Victoria ATP Binding Cassette Transporter, Subfamily B, Member 1 |
| Description: | Copyright © 2004 American Academy of Neurology |
| DOI: | 10.1212/01.WNL.0000137051.33486.C7 |
| Description (link): | http://www.neurology.org/cgi/content/abstract/63/6/1090 |
| Published version: | http://dx.doi.org/10.1212/01.wnl.0000137051.33486.c7 |
| Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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