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|Title:||Toxic shock syndrome associated with newly diagnosed type 1 diabetes|
|Citation:||Journal of Paediatrics and Child Health, 2000; 36(3):279-282|
|Publisher:||Blackwell Publishing Asia|
|Abstract:||Studies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet infiltrating T cells by a superantigen. We present the first reported case of a superantigen mediated disease, toxic shock syndrome (TSS), occurring at the diagnosis of type I diabetes. A 12-year-old girl presented with TSS and newly diagnosed diabetes with ketoacidosis. At presentation she was unconscious, febrile and hypotensive, with a desquamating erythematous rash and Kussmaul breathing. During resuscitation, her renal impairment, diarrhoea, thrombocytopaenia and ketoacidosis resolved. Vaginal discharge and blood cultures grew Staphylococcus aureus. T cell studies at 2 weeks after diagnosis detected a high level of spontaneous and islet antigen-specific proliferation with associated interleukin-10 production compared to human leucocyte antigen DR matched controls.|
|Keywords:||Humans; Staphylococcal Infections; Shock, Septic; Diabetes Mellitus, Type 1; Autoimmune Diseases; Insulin; Superantigens; Anti-Bacterial Agents; Follow-Up Studies; Child; Female|
|Appears in Collections:||Paediatrics publications|
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