Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/32914
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dc.contributor.authorCouper, J.-
dc.contributor.authorKallincos, N.-
dc.contributor.authorPollard, A.-
dc.contributor.authorHoneyman, M.-
dc.contributor.authorPrager, P.-
dc.contributor.authorHarrison, L.-
dc.contributor.authorRischmueller, M.-
dc.date.issued2000-
dc.identifier.citationJournal of Paediatrics and Child Health, 2000; 36(3):279-282-
dc.identifier.issn1034-4810-
dc.identifier.issn1440-1754-
dc.identifier.urihttp://hdl.handle.net/2440/32914-
dc.description.abstractStudies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet infiltrating T cells by a superantigen. We present the first reported case of a superantigen mediated disease, toxic shock syndrome (TSS), occurring at the diagnosis of type I diabetes. A 12-year-old girl presented with TSS and newly diagnosed diabetes with ketoacidosis. At presentation she was unconscious, febrile and hypotensive, with a desquamating erythematous rash and Kussmaul breathing. During resuscitation, her renal impairment, diarrhoea, thrombocytopaenia and ketoacidosis resolved. Vaginal discharge and blood cultures grew Staphylococcus aureus. T cell studies at 2 weeks after diagnosis detected a high level of spontaneous and islet antigen-specific proliferation with associated interleukin-10 production compared to human leucocyte antigen DR matched controls.-
dc.language.isoen-
dc.publisherBlackwell Publishing Asia-
dc.subjectHumans-
dc.subjectStaphylococcal Infections-
dc.subjectShock, Septic-
dc.subjectDiabetes Mellitus, Type 1-
dc.subjectAutoimmune Diseases-
dc.subjectInsulin-
dc.subjectSuperantigens-
dc.subjectAnti-Bacterial Agents-
dc.subjectFollow-Up Studies-
dc.subjectChild-
dc.subjectFemale-
dc.titleToxic shock syndrome associated with newly diagnosed type 1 diabetes-
dc.typeJournal article-
dc.identifier.doi10.1046/j.1440-1754.2000.00475.x-
pubs.publication-statusPublished-
dc.identifier.orcidCouper, J. [0000-0003-4448-8629]-
dc.identifier.orcidRischmueller, M. [0000-0001-5057-3286]-
Appears in Collections:Aurora harvest 6
Paediatrics publications

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