Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/32914
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Couper, J. | - |
dc.contributor.author | Kallincos, N. | - |
dc.contributor.author | Pollard, A. | - |
dc.contributor.author | Honeyman, M. | - |
dc.contributor.author | Prager, P. | - |
dc.contributor.author | Harrison, L. | - |
dc.contributor.author | Rischmueller, M. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Journal of Paediatrics and Child Health, 2000; 36(3):279-282 | - |
dc.identifier.issn | 1034-4810 | - |
dc.identifier.issn | 1440-1754 | - |
dc.identifier.uri | http://hdl.handle.net/2440/32914 | - |
dc.description.abstract | Studies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet infiltrating T cells by a superantigen. We present the first reported case of a superantigen mediated disease, toxic shock syndrome (TSS), occurring at the diagnosis of type I diabetes. A 12-year-old girl presented with TSS and newly diagnosed diabetes with ketoacidosis. At presentation she was unconscious, febrile and hypotensive, with a desquamating erythematous rash and Kussmaul breathing. During resuscitation, her renal impairment, diarrhoea, thrombocytopaenia and ketoacidosis resolved. Vaginal discharge and blood cultures grew Staphylococcus aureus. T cell studies at 2 weeks after diagnosis detected a high level of spontaneous and islet antigen-specific proliferation with associated interleukin-10 production compared to human leucocyte antigen DR matched controls. | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Asia | - |
dc.source.uri | http://dx.doi.org/10.1046/j.1440-1754.2000.00475.x | - |
dc.subject | Humans | - |
dc.subject | Staphylococcal Infections | - |
dc.subject | Shock, Septic | - |
dc.subject | Diabetes Mellitus, Type 1 | - |
dc.subject | Autoimmune Diseases | - |
dc.subject | Insulin | - |
dc.subject | Superantigens | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Child | - |
dc.subject | Female | - |
dc.title | Toxic shock syndrome associated with newly diagnosed type 1 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1440-1754.2000.00475.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Couper, J. [0000-0003-4448-8629] | - |
dc.identifier.orcid | Rischmueller, M. [0000-0001-5057-3286] | - |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.