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https://hdl.handle.net/2440/32914
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Type: | Journal article |
Title: | Toxic shock syndrome associated with newly diagnosed type 1 diabetes |
Author: | Couper, J. Kallincos, N. Pollard, A. Honeyman, M. Prager, P. Harrison, L. Rischmueller, M. |
Citation: | Journal of Paediatrics and Child Health, 2000; 36(3):279-282 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2000 |
ISSN: | 1034-4810 1440-1754 |
Abstract: | Studies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet infiltrating T cells by a superantigen. We present the first reported case of a superantigen mediated disease, toxic shock syndrome (TSS), occurring at the diagnosis of type I diabetes. A 12-year-old girl presented with TSS and newly diagnosed diabetes with ketoacidosis. At presentation she was unconscious, febrile and hypotensive, with a desquamating erythematous rash and Kussmaul breathing. During resuscitation, her renal impairment, diarrhoea, thrombocytopaenia and ketoacidosis resolved. Vaginal discharge and blood cultures grew Staphylococcus aureus. T cell studies at 2 weeks after diagnosis detected a high level of spontaneous and islet antigen-specific proliferation with associated interleukin-10 production compared to human leucocyte antigen DR matched controls. |
Keywords: | Humans Staphylococcal Infections Shock, Septic Diabetes Mellitus, Type 1 Autoimmune Diseases Insulin Superantigens Anti-Bacterial Agents Follow-Up Studies Child Female |
DOI: | 10.1046/j.1440-1754.2000.00475.x |
Published version: | http://dx.doi.org/10.1046/j.1440-1754.2000.00475.x |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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