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Type: Journal article
Title: Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?
Author: Rayner, C.
Horowitz, M.
Citation: Journal of Clinical Investigation, 2006; 116(2):299-302
Publisher: Amer Soc Clinical Investigation Inc
Issue Date: 2006
ISSN: 0021-9738
Statement of
Christopher K. Rayner and Michael Horowitz
Abstract: Upper gastrointestinal dysfunction occurs frequently in diabetes and potentially contributes to both abdominal symptoms and impaired glycemic control; conversely, variations in blood glucose concentration reversibly affect gut motility in humans. In this issue of the JCI, Anitha et al. report apoptosis of rodent enteric neurons under hyperglycemic conditions, both in vitro and in vivo, associated with impaired PI3K activity and preventable by glial cell line–derived neurotrophic factor (see the related article beginning on page 344). These observations add to recent insights gained from animal models regarding the etiology of diabetic gastrointestinal dysfunction, but investigators must strive to translate animal data to human diabetes.
Keywords: Animals; Humans; Gastrointestinal Diseases; Diabetes Mellitus; Diabetes Complications; Blood Glucose; Gastrointestinal Motility; Phosphatidylinositol 3-Kinases
Description: Copyright © 2006 by the American Society for Clinical Investigation
RMID: 0020061786
DOI: 10.1172/JCI27758
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Appears in Collections:Medicine publications

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