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https://hdl.handle.net/2440/33878
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Type: | Journal article |
Title: | Pseudoanaphylaxis |
Author: | Russell, W. Smith, W. |
Citation: | Anaesthesia and Intensive Care, 2006; 34(6):801-803 |
Publisher: | Australian Soc Anaesthetists |
Issue Date: | 2006 |
ISSN: | 0310-057X 1448-0271 |
Abstract: | Profound hypotension and cardiac arrest after commencement of combined spinal and general anaesthesia in a patient for knee replacement surgery raised the suspicion of anaphylaxis. This seemed to be confirmed when a mast cell tryptase test taken about 90 minutes after the onset of the hypotension was elevated. However, subsequent intradermal skin testing twelve weeks later did not identify a causal drug. Repeat mast cell tryptase at the time showed the same elevation, which led to the correct diagnosis of mastocytosis and a secondary diagnosis that the patient’s hypotension and cardiac arrest were the result of her spinal anaesthesia. If the serum tryptase is elevated during the event but no allergic agent can be identified, a further serum tryptase should be taken several weeks later to exclude a persistent elevation due to mastocytosis. |
Keywords: | Mast Cells Humans Mastocytosis Heart Arrest Hypotension Anaphylaxis Intraoperative Complications Diagnosis, Differential Arthroplasty, Replacement, Knee Middle Aged Female Tryptases Clinical Enzyme Tests Biomarkers |
DOI: | 10.1177/0310057x0603400618 |
Description (link): | http://www.aaic.net.au/Article.asp?D=2006364 |
Published version: | http://dx.doi.org/10.1177/0310057x0603400618 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest |
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