Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/34524
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Type: Journal article
Title: Studies toward the total synthesis of the variolins: rapid entry to the core structure
Author: Anderson, Regan James
Morris, Jonathan Charles
Citation: Tetrahedron Letters, 2001; 42(2):311-313
Publisher: Pergamon / Elsevier
Issue Date: 2001
ISSN: 0040-4039
School/Discipline: School of Chemistry and Physics : Chemistry
Statement of
Responsibility: 
Regan J. Anderson and Jonathan C. Morris
Abstract: The pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine core structure of the variolins has been synthesized in three steps from commercially available materials. The key reaction involves the deoxygenation and concomitant cyclization of a triarylmethanol using the combination of triethylsilane and trifluoroacetic acid. Introduction of amine functionality as required for the natural products has been achieved in two steps.
Keywords: Alkaloids; pyridines; pyrimidines; deoxygenation; cyclization
DOI: 10.1016/S0040-4039(00)01772-X
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/233/description#description
Appears in Collections:Chemistry and Physics publications

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