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Type: Journal article
Title: Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: Mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05)
Author: Roos, D.
Wirth, A.
Burmeister, B.
Spry, N.
Drummond, K.
Beresford, J.
McClure, B.
Citation: Radiotherapy and Oncology, 2006; 80(3):318-322
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2006
ISSN: 0167-8140
Statement of
Roos, Daniel E. ; Wirth, Andrew ; Burmeister, Bryan H. ; Spry, Nigel A. ; Drummond, Katharine J. ; Beresford, Jennifer A. ; McClure, Beverley E.
Abstract: We evaluated the effect of adjuvant whole brain irradiation (WBI) after surgery or radiosurgery for solitary brain metastases in a Phase III multicentre trial with randomization to 30-36 Gy WBI or observation. The study was closed early due to slow accrual after 19 patients (WBI 10, observation 9). There was no difference in CNS failure-free survival or overall survival between the arms. There was a trend to reduced CNS relapse with WBI (30% versus 78%, P=0.12). Limited analysis of quality of life and neurocognitive function data revealed no evidence of difference between the arms. Our results are not inconsistent with two larger randomized trials and support the use of upfront WBI to decrease brain recurrence in this setting.
Keywords: Radiosurgery; Solitary brain metastases; Surgery; Whole brain irradiation
RMID: 0020061561
DOI: 10.1016/j.radonc.2006.08.004
Appears in Collections:Medicine publications

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