Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34701
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Type: Journal article
Title: Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging
Author: Corti, R.
Fayad, Z.
Fuster, V.
Worthley, S.
Helft, G.
Cheesebro, J.
Mercuri, M.
Badimon, J.
Citation: Circulation, 2001; 104(3):249-252
Publisher: Lippincott Williams & Wilkins
Issue Date: 2001
ISSN: 0009-7322
1524-4539
Statement of
Responsibility: 
Roberto Corti, Zahi A. Fayad, Valentin Fuster, Stephen G. Worthley, Gerard Helft, James Chesebro, Michele Mercuri, and Juan J. Badimon
Abstract: <h4>Background</h4>This study was designed to investigate the effects of lipid-lowering by simvastatin on human atherosclerotic lesions.<h4>Methods and results</h4>Eighteen asymptomatic hypercholesterolemic patients with documented aortic and/or carotid atherosclerotic plaques were selected for the study. A total of 35 aortic and 25 carotid artery plaques were detected. Serial black-blood MRI of the aorta and carotid artery of the patients was performed at baseline and 6 and 12 months after lipid-lowering therapy with simvastatin. The effects of the treatment on atherosclerotic lesions were measured as changes in lumen area, vessel wall thickness, and vessel wall area, a surrogate of atherosclerotic burden. Simvastatin induced a significant (P<0.01) reduction in total and LDL cholesterol levels at 6 weeks that was maintained thereafter. At 6 months, no changes in lumen area, vessel wall thickness, or vessel wall area were observed. However, at 12 months, significant reductions in vessel wall thickness and vessel wall area, without changes in lumen area, were observed in both aortic and carotid arteries (P<0.001).<h4>Conclusions</h4>This in vivo human study demonstrates that effective and maintained lipid-lowering therapy by simvastatin is associated with a significant regression of atherosclerotic lesions. Our observation suggests that statins induce vascular remodeling, as manifested by reduced atherosclerotic burden without changes in the lumen.
Keywords: Lipids; atherosclerosis; plaque; magnetic resonance imaging
Rights: © 2001 American Heart Association, Inc.
RMID: 0020064339
DOI: 10.1161/01.CIR.104.3.249
Published version: http://circ.ahajournals.org/cgi/content/full/104/3/249
Appears in Collections:Medicine publications

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