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Type: Journal article
Title: A platypus’ eye view of the mammalian genome
Author: Grutzner, F.
Graves, J.
Citation: Current Opinion in Genetics & Development, 2004; 14(6):642-649
Publisher: Current Biology Ltd
Issue Date: 2004
ISSN: 0959-437X
Statement of
Frank Grützner and Jennifer A Marshall Graves
Abstract: The genome of monotremes, like the animals themselves, is unique and strange. The importance of monotremes to genomics depends on their position as the earliest offshoot of the mammalian lineage. Although there has been controversy in the literature over the phylogenetic position of monotremes, this traditional interpretation is now confirmed by recent sequence comparisons. Characterizing the monotreme genome will therefore be important for studying the evolution and organization of the mammalian genome, and the proposal to sequence the platypus genome has been received enthusiastically by the genomics community. Recent investigations of X-chromosome inactivation, genomic imprinting and sex chromosome evolution provide good examples of the power of the monotreme genome to inform us about mammalian genome organization and evolution.
Keywords: Sex Chromosomes; Animals; Platypus; Genomic Imprinting; Genome; Biological Evolution
Description: Copyright © 2004 Elsevier
RMID: 0020063225
DOI: 10.1016/j.gde.2004.09.006
Published version:
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute Leaders publications

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