Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34823
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Type: Journal article
Title: Species-specific evolution of repeated DNA sequences in great apes
Author: Toder, R.
Grutzner, F.
Haaf, T.
Bausch, E.
Citation: Chromosome Research, 2001; 9(6):431-435
Publisher: Kluwer Academic Publ
Issue Date: 2001
ISSN: 0967-3849
1573-6849
Statement of
Responsibility: 
R. Toder, F. Grützner, T. Haaf, E. Bausch
Abstract: DNA sequencing reveals that the genomes of the human, gorilla and chimpanzee share more than 98% homology. Comparative chromosome painting and gene mapping have demonstrated that only a few rearrangements of a putative ancestral mammalian genome occurred during great ape and human evolution. However, interspecies representational difference analysis (RDA) of the gorilla between human and gorilla revealed gorilla-specific DNA sequences. Cloning and sequencing of gorilla-specific DNA sequences indicate that there are repetitive elements. Gorilla-specific DNA sequences were mapped by fluorescence in-situ hybridization (FISH) to the subcentromeric/centromeric regions of three pairs of gorilla submetacentric chromosomes. These sequences could represent either ancient sequences that got lost in other species, such as human and orang-utan, or, more likely, recent sequences which evolved or originated specifically in the gorilla genome.
Keywords: genome evolution - species-specific DNA sequences
Description: The original publication can be found at www.springerlink.com
RMID: 0020064693
DOI: 10.1023/A:1011605824530
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute Leaders publications

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