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|Title:||Species-specific evolution of repeated DNA sequences in great apes|
|Citation:||Chromosome Research, 2001; 9(6):431-435|
|Publisher:||Kluwer Academic Publ|
|R. Toder, F. Grützner, T. Haaf, E. Bausch|
|Abstract:||DNA sequencing reveals that the genomes of the human, gorilla and chimpanzee share more than 98% homology. Comparative chromosome painting and gene mapping have demonstrated that only a few rearrangements of a putative ancestral mammalian genome occurred during great ape and human evolution. However, interspecies representational difference analysis (RDA) of the gorilla between human and gorilla revealed gorilla-specific DNA sequences. Cloning and sequencing of gorilla-specific DNA sequences indicate that there are repetitive elements. Gorilla-specific DNA sequences were mapped by fluorescence in-situ hybridization (FISH) to the subcentromeric/centromeric regions of three pairs of gorilla submetacentric chromosomes. These sequences could represent either ancient sequences that got lost in other species, such as human and orang-utan, or, more likely, recent sequences which evolved or originated specifically in the gorilla genome.|
|Keywords:||genome evolution - species-specific DNA sequences|
|Description:||The original publication can be found at www.springerlink.com|
|Appears in Collections:||Molecular and Biomedical Science publications|
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