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|Title:||Comparative mapping of the human 9q34 region in Fugu rubripes|
|Citation:||Cytogenetic and Genome Research, 2001; 94(3-4):173-179|
|Bouchireb N, Grützner F, Haaf T, Stephens R.J, Elgar G, Green A. J and Clark M. S.|
|Abstract:||Twenty-seven genes have been cloned and mapped in Fugu which have orthologues within the human chromosome 9q34 region. The genes are arranged into five cosmid and BAC contigs which physically map to two different Fugu chromosomes. Considering the gene content of these contigs, it is more probable that a translocation event took place early in the Fugu lineage to split the ancestral 9q34 region onto two chromosomes rather than the alternative hypothesis of a large-scale duplication of the region into two chromosomes with subsequent rapid and dramatic gene loss. There are considerable differences in gene order between the two species, which would appear to be the result of a series of complex chromosome inversions; thus suggesting that there have been no positional constraints on this particular gene set.|
|Keywords:||Chromosomes; Chromosomes, Artificial, Bacterial; Chromosomes, Human, Pair 9; Animals; Takifugu; Humans; Inversion, Chromosome; Translocation, Genetic; Fish Proteins; In Situ Hybridization, Fluorescence; Contig Mapping; Species Specificity; Gene Duplication; Conserved Sequence; Sequence Homology, Nucleic Acid; Gene Order; Multigene Family; Cosmids|
|Appears in Collections:||Molecular and Biomedical Science publications|
Environment Institute Leaders publications
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