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Type: Journal article
Title: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation
Author: Lando, D.
Gorman, J.
Whitelaw, M.
Peet, D.
Citation: FEBS Journal, 2003; 270(5):781-790
Publisher: Blackwell Publishing Ltd
Issue Date: 2003
ISSN: 1742-464X
Organisation: Centre for the Molecular Genetics of Development
Statement of
David Lando, Jeffrey J. Gorman, Murray L. Whitelaw and Daniel J. Peet
Abstract: To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency.
Keywords: oxygen sensing; hypoxia; hydroxylation; transcriptional regulation; hypoxia-inducible factor (HIF)
Description: European Journal of Biochemistry changed its name to FEBS Journal in January 2005
RMID: 0020064740
DOI: 10.1046/j.1432-1033.2003.03445.x
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Appears in Collections:Molecular and Biomedical Science publications
Centre for the Molecular Genetics of Development publications

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