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|Title:||Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation|
|Citation:||FEBS Journal, 2003; 270(5):781-790|
|Publisher:||Blackwell Publishing Ltd|
|Organisation:||Centre for the Molecular Genetics of Development|
|David Lando, Jeffrey J. Gorman, Murray L. Whitelaw and Daniel J. Peet|
|Abstract:||To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency.|
|Keywords:||oxygen sensing; hypoxia; hydroxylation; transcriptional regulation; hypoxia-inducible factor (HIF)|
|Description:||European Journal of Biochemistry changed its name to FEBS Journal in January 2005|
|Appears in Collections:||Molecular and Biomedical Science publications|
Centre for the Molecular Genetics of Development publications
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