Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34883
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Type: Journal article
Title: Synthesis and protein conjugation studies of vitamin K analogues
Author: Payne, R.
Daines, A.
Clark, B.
Abell, A.
Citation: Bioorganic & Medicinal Chemistry, 2004; 12(22):5785-5791
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2004
ISSN: 0968-0896
1464-3391
Statement of
Responsibility: 
Richard J. Payne, Alison M. Daines, Bruce M. Clark and Andrew D. Abell
Abstract: Two vitamin K analogues bearing a carboxylic acid side chain (9a and its deuterated analogue 9b) were each synthesised in six steps from commercially available menadione. Analogue 9b was conjugated to lysozyme and bovine serum albumin (BSA) using EDCI/HOBT and by prior formation of its activated succinimidyl ester 11. Quantification of the thus formed conjugates by ESMS and LC–MS revealed that the number of equivalents of the analogue used in the couplings systematically controls the number of analogues that conjugate to the protein.
Keywords: Vitamin K; Analogue synthesis; Protein conjugation; Mass spectrometry
Description: Copyright © 2004 Elsevier Ltd All rights reserved.
RMID: 0020064466
DOI: 10.1016/j.bmc.2004.08.037
Description (link): http://www.sciencedirect.com/science/journal/09680896
Appears in Collections:Chemistry publications

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