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Type: Book chapter
Title: Streptococcus pneumoniae Capsular Polysaccharide
Author: Paton, J.
Morona, J.
Citation: Gram-positive pathogens, 2006 / Fischetti, V., Novick, R., Ferretti, J., Portnoy, D., Rood, J. (ed./s), Ch.ARTN GPP3-0019-2018, pp.241-252
Publisher: American Society for Microbiology Press
Publisher Place: 1752 N St, NW, Washington, DC 20036-2904
Issue Date: 2006
ISBN: 1555813437
Abstract: The polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure of the organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms. The capsule is the target of current pneumococcal vaccines, but there are 98 currently recognised polysaccharide serotypes and protection is strictly serotype-specific. Widespread use of these vaccines is driving changes in serotype prevalence in both carriage and disease. This chapter summarises current knowledge on the role of the capsule and its regulation in pathogenesis, the mechanisms of capsule synthesis, the genetic basis for serotype differences, and provides insights into how so many structurally distinct capsular serotypes have evolved. Such knowledge will inform ongoing refinement of pneumococcal vaccination strategies.
Keywords: Animals; Humans; Streptococcus pneumoniae; Polysaccharides, Bacterial; Bacterial Capsules; Pneumococcal Vaccines
RMID: 0020063787
DOI: 10.1128/microbiolspec.GPP3-0019-2018
Appears in Collections:Molecular and Biomedical Science publications

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