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dc.contributor.authorPaton, J.en
dc.contributor.authorMorona, J.en
dc.identifier.citationGram-positive pathogens, 2006 / Fischetti, V., Novick, R., Ferretti, J., Portnoy, D., Rood, J. (ed./s), Ch.ARTN GPP3-0019-2018, pp.241-252en
dc.description.abstractThe polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure of the organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms. The capsule is the target of current pneumococcal vaccines, but there are 98 currently recognised polysaccharide serotypes and protection is strictly serotype-specific. Widespread use of these vaccines is driving changes in serotype prevalence in both carriage and disease. This chapter summarises current knowledge on the role of the capsule and its regulation in pathogenesis, the mechanisms of capsule synthesis, the genetic basis for serotype differences, and provides insights into how so many structurally distinct capsular serotypes have evolved. Such knowledge will inform ongoing refinement of pneumococcal vaccination strategies.en
dc.publisherAmerican Society for Microbiology Pressen
dc.subjectAnimals; Humans; Streptococcus pneumoniae; Polysaccharides, Bacterial; Bacterial Capsules; Pneumococcal Vaccinesen
dc.titleStreptococcus pneumoniae Capsular Polysaccharideen
dc.typeBook chapteren
dc.publisher.place1752 N St, NW, Washington, DC 20036-2904en
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]en
dc.identifier.orcidMorona, J. [0000-0002-4891-4122]en
Appears in Collections:Molecular and Biomedical Science publications

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