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Type: Journal article
Title: Antidepressants and inflammatory bowel disease: a systematic review
Author: Mikocka-Walus, A.
Turnbull, D.
Moulding, N.
Wilson, I.
Andrews, J.
Holtmann, G.
Citation: Clinical Practice and Epidemiology in Mental Health, 2006; 2(24):1-9
Publisher: BioMed Central Ltd,
Issue Date: 2006
ISSN: 1745-0179
Statement of
Antonina A Mikocka-Walus, Deborah A Turnbull, Nicole T Moulding, Ian G Wilson, Jane M Andrews and Gerald J Holtmann
Abstract: Background: A number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological co-morbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed. Methods: We searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined. Results: 12 relevant publications were identified. All of them referred to non-randomised studies. Antidepressants reported in these publications included paroxetine, bupropion, amitriptyline, phenelzine, and mirtazapine. In 10 articles, paroxetine, bupropion, and phenelzine were suggested to be effective for treating both psychological and somatic symptoms in patients suffering from IBD. Amitriptyline was found ineffective for treating somatic symptoms of IBD. Mirtazapine was not recommended for IBD patients. Conclusion: Although most of reviewed papers suggest a beneficial effect of treatment with antidepressants in patients with IBD, due to the lack of reliable data, it is impossible to judge the efficacy of antidepressants in IBD. Properly designed trials are justified and needed based upon the available uncontrolled data.
Rights: © 2006 Mikocka-Walus et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License(, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0020062569
DOI: 10.1186/1745-0179-2-24
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Appears in Collections:Psychology publications

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