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Type: Journal article
Title: The influence of gestation and mechanical ventilation on serum Clara cell secretory protein (CC10) concentrations in ventilated and nonventilated newborn infants
Author: Loughran-Fowlds, Alison
Oei, Julee
Wang, He
Xu, Hongxiu
Wimalasundera, Neil
Egan, Claire
Henry, Richard L.
Lui, Kei
Citation: Pediatric Research, 2006; 60 (1):103-108
Publisher: International Pediatric Research Foundation
Issue Date: 2006
ISSN: 0031-3998
School/Discipline: School of Population Health and Clinical Practice : Public Health
Statement of
Alison Loughran-Fowlds, Julee Oei, He Wang, Hongxiu Xu, Neil Wimalasundera, Claire Egan, Richard Henry and Kei Lui
Abstract: Clara cell secretory protein (CC10) is an important anti-inflammatory mediator in the adult lung, but its role in newborn pulmonary protection is uncertain. We examined the early postnatal behavior of CC10 in newborn serum and tracheal fluid and hypothesized that CC10 production is positively influenced by gestation. Blood from 165 infants from the first, third/fourth, and seventh days of life (gestational ages: 23-29 wk, 30-36 wk, >36 wk) and tracheal fluid (TF) from the first day of life from 32 ventilated infants were analyzed for CC10. Surfactant proteins A (SPA) and B (SPB) were also analyzed from the blood of a subgroup of infants. Serum CC10 on day 1 was highest in term infants (69.4 ng/mL), followed by moderately preterm (55.8 ng/mL), and then extremely preterm infants (median 42.1 ng/mL). Term infants also had higher tracheal fluid CC10 than preterm infants. (20.152 ng/mL versus 882 ng/mL). Mechanical ventilation increased serum CC10 only in moderately preterm infants, and only on d 1 [68.4 ng/mL versus 42.1 ng/mL (nonventilated moderately preterm infants)]. Serum CC10 decreased progressively by the end of the first week in all infants, in contrast to SPA and SPB, which increased. Our results show that CC10 is detectable in the blood of newborn infants and that a production surge occurs at birth. This surge is more pronounced in term infants and may confer them with superior extrauterine pulmonary protection compared with preterm infants.
Description: Copyright © 2006 International Pediatric Research Foundation, Inc.
RMID: 0020062616
DOI: 10.1203/01.pdr.0000219388.56608.77
Appears in Collections:Public Health publications

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