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Type: Journal article
Title: Long-standing type II diabetes mellitus is not a risk factor for slow gastric emptying in critically ill patients
Author: Nguyen, Q.
Chapman, M.
Fraser, R.
Ritz, M.
Bryant, L.
Butler, R.
Davidson, G.
Zacharakis, B.
Holloway, R.
Citation: Intensive Care Medicine, 2006; 32(9):1365-1370
Publisher: Springer
Issue Date: 2006
ISSN: 0342-4642
Abstract: <h4>Objective</h4>Delayed gastric emptying (GE) is common both in critical illness and in patients with diabetes mellitus (DM). The effect of DM on the incidence of slow GE in these patients is unknown. We evaluated the effect of DM on liquid GE in critically ill patients.<h4>Methods</h4>Retrospective analysis of GE using a standard [13C]octanoic acid breath test in 12 type 2 DM patients compared with (a) 44 critically ill patients without DM, including (b) a subgroup of 15 age- and sex-matched patients and (c) 15 healthy volunteers. We determined the gastric emptying coefficient (GEC) and the gastric half-emptying time (t50). Mean APACHE II scores, blood glucose levels and use of morphine were similar between patient groups.<h4>Results</h4>GE was faster in critically ill patients with DM (t50 122 +/- 11 min, GEC: 3.8 +/- 0.3) than in patients without DM (t50 168 +/- 16 min, GEC 2.8 +/- 0.1) and in age- and sex-matched controls (t50 165 +/- 13 min, GEC 2.7 +/- 0.2) and was similar to that in healthy volunteers (t50 148 +/- 13 min, GEC 3.5 +/- 0.1). The proportion of patients with slow emptying (GEC < 3.2) was greater in non-DM (all = 56%, matched = 60%) than in DM patients (25%) and healthy subjects (26%).<h4>Conclusion</h4>Long-standing type diabetes mellitus is not a risk factor for slow GE in critically ill patients.
Keywords: Humans
Diabetes Mellitus, Type 2
Critical Illness
Breath Tests
Respiration, Artificial
Risk Factors
Chi-Square Distribution
Case-Control Studies
Retrospective Studies
Gastric Emptying
Middle Aged
DOI: 10.1007/s00134-006-0228-0
Appears in Collections:Anaesthesia and Intensive Care publications
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