Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/35684
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Type: Journal article
Title: The FEV1/FEV6 ratio is a good substitute for the FEV1/FVC ration in the elderly
Author: Melbye, H.
Medbo, A.
Crockett, A.
Citation: Primary Care Respiratory Journal, 2006; 15(5):294-298
Publisher: Strategic Medical Publishing
Issue Date: 2006
ISSN: 1471-4418
1475-1534
Statement of
Responsibility: 
Hasse Melbye, Astri Medbø and Alan Crockett
Abstract: <h4>Aims</h4>To determine the agreement between the FEV1/FEV6 ratio and the FEV1/FVC ratio in an elderly population.<h4>Method</h4>The study sample consisted of 3874 participants in a cross-sectional population survey in Tromsö, Norway, aged 60 years or more, in whom acceptable spirometry had been obtained. Mean differences between the FEV1/FEV6 ratio (%) and the FEV1/FVC ratio (%) were calculated according to age, sex, smoking habit, and the degree of airflow limitation. ROC-curve analysis and Kappa-statistics were used to estimate the utility of the FEV1/FEV6 ratio in predicting an FEV1/FVC ratio < 70%.<h4>Results</h4>The mean difference between FEV1/FEV6% and FEV1/FVC% was 2.7% in both men and women. The difference between the two measures increased somewhat with increasing age, and was more pronounced with smoking and decreasing FEV1/FVC ratio. The value for the FEV1/FEV6 ratio which best predicted an FEV1/FVC ratio of 70%, was 73%, and a very good agreement was found between these two cut-off values (kappa = 0.86).<h4>Conclusion</h4>The FEV1/FEV6 ratio appears to be a good substitute for the FEV1/FVC ratio in an elderly population.
Keywords: Spirometry; primary care; FEV1; FEV6; FVC
Rights: © Elsevier
RMID: 0020062688
DOI: 10.1016/j.pcrj.2006.07.002
Published version: http://www.thepcrj.org/journ/view_article.php?article_id=180&volissue=16
Appears in Collections:General Practice publications

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