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Type: Journal article
Title: How did the platypus get its sex chromosome chain? A comparison of meiotic multiples and sex chromosomes in plants and animals
Author: Grutzner, F.
Ashley, T.
Rowell, D.
Graves, J.
Citation: Chromosoma: biology of the nucleus, 2006; 115(2):75-88
Publisher: Springer
Issue Date: 2006
ISSN: 0009-5915
Statement of
Frank Gruetzner, Terry Ashley, David M. Rowell and Jennifer A. Marshall Graves
Abstract: The duck-billed platypus is an extraordinary mammal. Its chromosome complement is no less extraordinary, for it includes a system in which ten sex chromosomes form an extensive meiotic chain in males. Such meiotic multiples are unprecedented in vertebrates but occur sporadically in plant and invertebrate species. In this paper, we review the evolution and formation of meiotic multiples in plants and invertebrates to try to gain insights into the origin of the platypus meiotic multiple. We describe the meiotic hurdles that translocated mammalian chromosomes face, which make longer chains disadvantageous in mammals, and we discuss how sex chromosomes and dosage compensation might have affected the evolution of sex-linked meiotic multiples. We conclude that the evolutionary conservation of the chain in monotremes, the structural properties of the translocated chromosomes and the highly accurate segregation at meiosis make the platypus system remarkably different from meiotic multiples in other species. We discuss alternative evolutionary models, which fall broadly into two categories: either the chain is the result of a sequence of translocation events from an ancestral pair of sex chromosomes (Model I) or the entire chain came into being at once by hybridization of two populations with different chromosomal rearrangements sharing monobrachial homology (Model II).
Keywords: Chromosomes, Mammalian
Chromosomes, Plant
Sex Chromosomes
Translocation, Genetic
Evolution, Molecular
Chromosome Pairing
Rights: © Springer-Verlag 2005
DOI: 10.1007/s00412-005-0034-4
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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