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|Title:||A whole genome scan for differences in recombination rates among three Bos taurus breeds|
|Citation:||Mammalian Genome, 2001; 12(9):724-728|
|Hauke Thomsen, Norbert Reinsch, Ningying Xu, Jörn Bennewitz, Christian Looft, Sven Grupe, Christa Kühn, Gudrun A. Brockmann, Manfred Schwerin, Birgit Leyhe-Horn, Stefan Hiendleder, Georg Erhardt, Ivica Medjugorac, Ingolp Russ, Martin Förster, Bertram Brenig, Fritz Reinhardt, Reinhard Reents, Jürgen Blümel, Gottfried Averdunk, Ernst Kalm|
|Abstract:||Twenty paternal half-sib families of a granddaughter design were genotyped for 265 genetic markers, most of them microsatellites. These were 16 Holstein families, 3 Simmental families, and 1 Brown Swiss family. The number of sires per breed was 872, 170, and 32, respectively. Two-point recombination rates were estimated both jointly for all breeds and each single breed separately. Of 1168 marker intervals, 865 provided estimates for at least two breeds. Differences between breeds were tested by likelihood ratio tests. Four marker intervals, representing three genomic regions on BTA19, BTA24, and BTA27, show a significant impact of the breed at a false discovery rate of 0.23 and indicate a genetic component of observed heterogeneity of recombination. The variability of recombination rates between cattle breeds might not be a common feature of the whole genome, but rather might be restricted to certain chromosomal segments. Thus, attention should be paid to heterogeneities when pooling data of such regions from different breeds.|
|Keywords:||Animals; Cattle; Genetic Markers; Chromosome Mapping; Crosses, Genetic; Pedigree; Breeding; Meiosis; Recombination, Genetic; Microsatellite Repeats; Genotype; Female; Genetic Linkage|
|Description:||The original publication can be found at www.springerlink.com|
|Appears in Collections:||Agriculture, Food and Wine publications|
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