Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/36693
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Type: Journal article
Title: Quantitative trait loci mapping of functional traits in the German Holstein cattle population
Author: Kuhn, C.
Bennewitz, J.
Reinsch, N.
Xu, N.
Thomsen, H.
Looft, C.
Brockmann, G.
Schwerin, M.
Weimann, C.
Hiendleder, S.
Erhardt, G.
Medjugorac, I.
Forster, M.
Brenig, B.
Reinhardt, F.
Reents, R.
Russ, I.
Averdunk, G.
Blumel, J.
Kalm, E.
Citation: Journal of Dairy Science, 2003; 86(1):360-368
Publisher: Amer Dairy Science Assoc
Issue Date: 2003
ISSN: 0022-0302
1525-3198
Statement of
Responsibility: 
Ch. Kühn, J. Bennewitz, N. Reinsch, N. Xu, H. Thomsen, C. Looft, G. A. Brockmann, M. Schwerin, C. Weimann, S. Hiendleder, G. Erhardt, I. Medjugorac, M. Förster, B. Brenig, F. Reinhardt, R. Reents, I. Russ, G. Averdunk, J. Blümel and E. Kalm
Abstract: A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYSm, DYSd) and stillbirth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYSm on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Yps, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.
Keywords: Quantitative trait loci; functional traits; Holstein cattle
Description: Copyright © 2003 American Dairy Science Association
RMID: 0020065610
DOI: 10.3168/jds.S0022-0302(03)73614-5
Published version: http://jds.fass.org/cgi/content/abstract/86/1/360
Appears in Collections:Agriculture, Food and Wine publications

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